Weight-related disorders are those disorders which are caused due to the extra body weight. An increased body mass index (BMI) raises the risk of developing non-communicable diseases and disorders, like musculoskeletal disorders, diabetes and cardiovascular disease, which significantly reduces life expectancy and quality of life. Obesity is common in adolescents in which the accumulation of excess body fat causes a detrimental impact on health. It is caused by a long-term energy imbalance between calories ingested and calories burned. Weight related disorders results in various disorders, such as chronic kidney disease (CKD), depression, metabolic syndrome (MetS), nonalcoholic fatty liver disease (NAFLD), obstructive sleep apnea, hyperlipidemia, certain types of cancer, osteoarthritis, hypertension, etc. There are various treatment options available for obesity, including bariatric surgery, lifestyle changes, fecal microbiota transplantation and anti-obesity medications. This book contains detailed explanation of the pathophysiology and therapeutics associated with weight-related disorders. It will help new researchers by foregrounding their knowledge in this condition.