The symptoms of venous insufficiency may be benign, like heavy and tired legs, but may also be much more serious, like varicose veins, painful hemorrhoids and even phlebitis.   Medicinal ingredient: Extract of fresh Horse chestnut (Aesculus hippocastanum L.) seed (ratio 5:1)...................... 191.25 mg,equivalent to 956.25 mg dried seed, standardized to 50 mg (22-32%) aescin per tablet. Non-medicinal ingredients: Microcrystalline cellulose, corn starch, methacrylic acid copolymer, copovidone, colloidal silicon dioxyde, soya polysaccharides, talc, triethyl citrate.Sugar, lactose and gluten free. Adults: Take 1 tablet twice daily, every 12 hours, with water during meals.