This volume constitutes the proceedings of the 10th IFIP WG 8.1 Conference on the Practice of Enterprise Modeling held in November 2017 in Leuven, Belgium. The conference was created by the International Federation for Information Processing (IFIP) Working Group 8.1 to offer a forum for knowledge transfer and experience sharing between the academic and practitioner communities. The 20 full papers and 4 short papers accepted were carefully reviewed and selected from 70 submissions. They include research results, practitioner/experience reports and work-in-progress papers and were presented in 8 sessions covering diverse topics related to enterprise modelling and its application in practice.