Structural Genomics and Drug Discovery: Methods and Protocols focuseson high throughput structure determination methods and how they can be applied to lay the groundwork for structure aided drug discovery. The methods and protocols that are described can be applied in any laboratory interested in using detailed structural information to advance the initial stages of drug discovery. Written in the highly successfulMethods in Molecular Biologyseries format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.Authoritative and practical,Structural Genomics and Drug Discovery: Methods and Protocolsseeks to aid scientists in the further study intostructural genomics approach as an efficient initial step toward drug discovery and the methods described will be useful to anyone interested in moving in this direction.