Southern Comfort is an iconic American liqueur created in 1874 in New Orleans. It is a whisky-based liqueur, spiced and sweetened, boasting notes of citrus, peach, honey, vanilla and cinnamon. It is a must-have for any home bar setup. Enjoy it neat, over ice, with sodas or in cocktails like the Alabama Slammer! Southern Comfort is an iconic American liqueur created in 1874 in New Orleans. It is a whisky-based liqueur, spiced and sweetened, boasting notes of citrus, peach, honey, vanilla and cinnamon. It is a must-have for any home bar setup. Enjoy it neat, over ice, with sodas or in cocktails like the Alabama Slammer! 375 mL bottle