Natural Factors Pycnogenol is made from the highest quality French maritime pine bark harvested from natural forests with no pesticides and no herbicides. Pycnogenol is one of the most potent natural antioxidants. Additionally, it is anti-inflammatory, increases nitric oxide levels, and supports collagen and hyaluronic acid production. Pycnogenol can help reduce symptoms of perimenopause and knee osteoarthritis and address age-associated inflammation and free radical damage.Medicinal IngredientsNon-Medicinal IngredientsMicrocrystalline cellulose, vegetarian capsule (carbohydrate gum [cellulose], purified water), vegetable grade magnesium stearate (lubricant).Pycnogenol French maritime pine bark extract is extracted from the bark of pine trees (Pinus pinaster) grown exclusively in Les Landes de Gascogne forest in southwest France near the famous Bordeaux region . The forest is an unspoiled and natural plantation with no pesticides and no herbicides . As one of the most potent natural scavengers of free radicals, Pycnogenol mops-up aggressive radicals before they cause damage by oxidative stress . Additionally, it acts as a natural anti-inflammatory, helps generate collagen and hyaluronic acid, and aids in the production of endothelial nitric oxide which helps to dilate blood vessels . Provides antioxidants for the maintenance of good health .