This book constitutes the first volume of the proceedings of the IUPESM World Congress on Medical Physics and Biomedical Engineering 2025, held in Adelaide, Australia, from September 29 to October 4, 2025. It presents recent research and developments in the fields of medical physics and biomedical engineering. The contributions address a broad range of topics including diagnostic imaging, radiotherapy, radiation protection, innovative applications of additive manufacturing, computational modelling, and artificial intelligence in medicine. The volume serves as a valuable reference for medical physicists, biomedical engineers, and healthcare professionals, offering insights into current challenges and emerging trends, and fostering interdisciplinary collaboration for future advancements in healthcare technology.