The book is a collection of best selected research papers presented at the International Conference on Recent Trends in Machine Learning, IoT, Smart Cities and Applications (ICMISC 2022) held during 28 - 29 March 2022 at CMR Institute of Technology, Hyderabad, Telangana, India. This book will contain the articles on current trends of machine learning, internet of things, and smart cities applications emphasizing on multi-disciplinary research in the area of artificial intelligence and cyber physical systems. The book is a great resource for scientists, research scholars and PG students to formulate their research ideas and find the future directions in these areas. Further, this book serves as a reference work to understand the latest technologies by practice engineers across the globe.