In this issue ofPET Clinics, guest editors Drs. Abass Alavi, Andrew B. Newberg, Poul Flemming Hoilund-Carlsen, and Eric Guedj bring their considerable expertise to the topic ofPET-CT-MRI in Central Nervous System Disorders with Emphasis on Dementias . Top experts in the field provide an overview of PET imaging in the most common dementias and brain diseases, such as Alzheimer&s and epilepsy. Specific articles also investigate normal brain aging, long COVID, brain trauma, and human experience and consciousness.