In this issue of Anesthesiology Clinics, guest editors Drs. Matthew M. McEvoy and James Abernathy III bring their considerable expertise to the topic of Perioperative Safety Culture. Safety culture is the product of individual and group values, attitudes, perceptions, competencies, and patterns of behavior that determine an organization's health and safety management. In this issue, top experts discuss topics such as patient safety and clinician wellness; handoffs and In-hospital care transitions; team dynamics in the operating room: how is team performance optimized?; anesthesiology operating room medication delivery; OR design: state-of-the-art design concepts to help mitigate errors and improve safety; and more.