Helps maintain healthy skin and helps to relieve joint pain associated with osteoarthritis of the hip and knee. Nature's Way Hydraplenish Plus MSM & Collagen contains the patented BioCell Collagen complex, plus OptiMSM. It has superior bioavailability due to its low molecular weigth hyaluronic acid. Hydraplenish Plus MSM & Collagen helps maintain healthy skin and helps to relieve joint pain associated with osteoarthritis of the hip and knee. Directions For skin health, adults take 1 capsule 2 times per day. For joint health, adults take 2 capsules 2 times per day. Use for a minimum of 1 month to see beneficial effects. For use beyond 3 months, consult a health care practitioner.