This book constitutes the proceedings of the 5th Iberoamerican Workshop on Human-Computer Interaction, HCI-Collab 2019, held in Puebla, Mexico, in June 2019. The 31 full papers presented in this volume were carefully reviewed and selected from 55 submissions. The papers describe models, design patterns, implementations, evaluations of existing applications, and systemic reviews; all of which are very important aspects within HCI.