Hepatolenticular degeneration, more commonly known as Wilson's disease, is a rare but serious genetic disorder of copper metabolism that affects the liver, brain, and other vital organs. This comprehensive book provides an in-depth exploration of the disease, from its molecular and genetic basis to its clinical presentation, diagnostic challenges, and modern therapeutic strategies. Readers will gain a clear understanding of how abnormal copper accumulation leads to progressive liver disease, neurological impairment, and psychiatric manifestations. The book also highlights current approaches in laboratory testing, imaging, and biopsy, as well as advances in pharmacological therapy and liver transplantation. Designed for medical students, healthcare professionals, and researchers, this text bridges fundamental science with practical clinical management. By presenting both historical insights and the latest evidence-based knowledge, it serves as an invaluable resource for anyone seeking to understand, diagnose, and treat hepatolenticular degeneration effectively.