In the face of recent viral outbreaks and a global viral pandemic, the necessity for innovation and continued rapid advancement in viral diagnosis and treatment methods has become even more apparent. Global Virology IV: Viral Disease Diagnosis and Treatment Delivery in the 21st Century explores the latest advances in virology and trends in clinical practice, focused on foundational principles and advancements expected to significantly impact this field. Chapters address SARS-CoV-2, Ebola, Zika, Mpox, and Hepatitis C, among other key viral threats, before presenting a detailed analysis of antiviral agents broadly and concerning specific vulnerable populations such as stem cell and solid organ transplant recipients. It is designed as a helpful resource for medical students, scientists, and professionals, bridging current practice and future applications and inspiring further innovations and improvements in global health.