Fracture, Fatigue, Failure, Damage Evolution and Thermomechanics & Infrared Imaging, Volume 4 of the Proceedings of the 2025 SEM Annual Conference & Exposition on Experimental and Applied Mechanics , the fourth volume of five from the Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on a wide range of areas, including: 3D Deformation and Failure In-situ Techniques and Microscale Effects on Mechanical Behavior Vibration and Cyclic Fatigue Integration of Models and Experiments Interface-Mediated Damage and Failure Fracture and Fatigue in Brittle Materials Material Characterizations Using Thermography Fatigue, Damage & Fracture Evaluation Using Infrared Thermography