This open access book constitutes the proceedings of the Second International Conference on Data Science and Exploration in Artificial Intelligence, CODE-AI 2025, which took place in Dubai, UAE, during April 7-8, 2025..The 67 full papers included in these proceedings were carefully reviewed and selected from 750 submissions.The thematic scope of CODE-AI 2025 spanned intelligent computing methods (including genetic algorithms, simulated annealing, artificial fish-swarm algorithms, quantum computing and fuzzy logic), advanced AI applications (such as biometrics, pattern recognition, computer and machine vision, speech recognition and smart robotics) and data-science topics (deep learning, decision-making frameworks, IoT/edge data integration and visualization.