This CCIS book constitutes selected papers accepted in the Research Tracks on Computational Science, Computational Intelligence, and Computational Biology of the 11th International Conference on Computational Science and Computational Intelligence, CSCI 2024, which took place in Las Vegas, NV, USA, during December 11-13, 2024.The 35 full papers included in this book were carefully reviewed and selected from a total of 180 submissions. They were organized in topical sections on computational science and applications; artificial intelligence and applications; scientific computing and HPC; health informatics and computational biology; and computational science and computational intelligence.