This book constitutes the refereed proceedings of the 13th International Conference, on Applications and Techniques in Information Security, ATIS 2022, held in Manipal, India, December 30-31, 2022. The 23 full papers included in this book were carefully reviewed and selected from 121 submissions. They were organized in topical sections as follows: Privacy and Security, Advances in Machine Learning, Cloud, IoT and Computing Technologies.