This book constitutes the refereed proceedings of the XXIInd International Conference on AIxIA 2023 - Advances in Artificial Intelligence, AIxIA 2023, held in Rome, Italy, during November 6-10, 2023. The 33 full papers  included in this book were carefully reviewed and selected from 53 submissions. They were organized in topical sections as follows: Argumentation and Logic Programming, Natural Language Processing, Machine Learning, Hybrid AI and Applications of AI.