This book emphasizes a balanced integration of foundational theoretical developments and innovative practical applications, with particular focus on Modern Technologies for Applied Artificial Intelligence and Big Data as well as AI in Life Sciences. Volume 1 of the Proceedings of the 4th International Conference on Advances in Information and Communication Technology (ICTA 2025) presents a rigorously curated collection of 2 keynote papers and 57 high-quality peer-reviewed research papers reflecting recent advances in core and applied areas of Information and Communication Technology. This book collectively highlights the expanding role of intelligent technologies in addressing complex scientific, technological, and socio-economic challenges. Published within the prestigious Lecture Notes in Networks and Systems (LNNS) series, Volume 1 serves as an authoritative scholarly resource for researchers, academic faculty, postgraduate students, and industry R&D professionals, supporting advanced research, teaching, and interdisciplinary collaboration.