The two-volume Proceedings set CCIS 1675 and 1676 constitutes the refereed proceedings of the Second International Conference, ARTIIS 2022, held in Santiago de Compostela, Spain, during September 12-15, 2022.  The 72 papers included in these proceedings were carefully reviewed and selected from 191 submissions. These papers were categorized into 2 technical tracks, i.e., Sustainability and Ethics, Security, and Privacy.